The AIDS virus It is a pathogen that attacks our immune system, leaving us vulnerable to other possible infections and diseases.
Once it has entered our body, the AIDS virus begin to reduce the population of CD4 lymphocytes, our major antibody factors and the best allies that the immune system has in our body.
Designing a vaccine against this virus is still considered a challenge, but on March 3 a study led by researchers from the Dake Human vaccine Institute and the Vaccine Research Center of the National Institute of Allergy and Ifectious Diseases (NIAID) have discovered rare antibodiesin an HIV patient who could cope with this disease.
Six Years Studying Possible Antibodies Against HIV
The finding has been published in the prestigious magazine Cell, and is the consequence of more than 6 years of work. A line of HIV antibodies, but the line recently identified by the doctor's group Duke Human Vaccine Institute and author of the article Mattia Bonsignori, far exceeds expectations.
This investigation would not have been possible without the identification 6 years ago of a person in Africa who was diagnosed with HIV in just a few weeks after the infection and that he was able to offer blood samples periodically.
Thanks to the periodic supply, we were able to analyze the structural changes and the evolution of both the virus and the antibodies. Mattia says.
Neutralizing antibodies, the hope against AIDS
As the AIDS virus mutates easily, it was important to know exactly what happens when it interacts with the antibodies, and in the case of vaccines, how it will interact with the antibody so that it becomes a neutralizing antibody.
Using these antibodies, we would be able to establish an effective method that would allow healthy people to acquirevirus protection.
Even so, many factors remain in play that allow such a vaccine to overcome the preclinical phases and reach the market. Recreating the route to synthesize these antibodies will not be easy, says Mattia, but it is not impossible.
At the moment, the team of the director of the Duke Human Vaccine Institute Barton F. Haynes, they are working on the first designs already in the animal model, and they are still investigating any other mechanism that can help us boost our immune system and prevent AIDS infection.
Source | AAAS