We have heard all our lives that there is a bad cholesterol for our health, and a good one. However, the latter may not be as good as we create.
Two cholesterol, the LDL (Low Density Lipoprotein) or bad cholesterol, since it has been continuously related to cardiovascular health problems, and the HDL (High Density Lipoprotein) or good cholesterol, because it does not achieve the same effect as its first cousin LDL.
This dichotomy has been restated with the latest study published in the prestigious magazine Science, with a genomic database of 852 people with high levels of HDLin the blood, compared to 1,156 people with low HDL.
A mutation alters the role of good cholesterol (HDL) in cardiovascular health
It's funny how throughout my academic career, I have been taught different concepts about cholesterol. At first, there are two cholesterol, one good for the heart and one bad. And after entering the race, they clarified to me that none were good or bad, simply that they must be at levels like any other metabolite in the body.
Bad cholesterol (LDL) accumulation has been associated with cardiac arrest and cardiovascular disease by stacking and obstructing the blood vessels, hindering blood flow. We know this thanks to the infinity of investigations at different levels, which have shown how drugs that reduce their levels help against the appearance of these diseases.
However, what corresponds to HDL, is based on doubtful correlations that as a general rule associated good cardiovascular health with high levels of HDL. The role of safeguarding heart health seems less and less clear.
A determining study on good cholesterol?
Although they would only find 19 people with copies of the mutation in their genes, the results have shown how high levels of HDL they can also be harmful. But on the other hand, SR-BI may be involved in another physiological process that negatively affects our cardiovascular health, leaving intact the role of HDL.
One thing is clear, low levels of good cholesterol or HDL are bad for our health, and we still don't know why. Little by little we will stop calling good cholesterol, at the same time that we know for sure its role in our metabolism.
Source | Pubmed